Endocrine Abstracts

Background: Kisspeptin is an endogenous neuropeptide that regulates GnRH release from the hypothalamus. Kisspeptin-54 has been shown to effectively trigger oocyte maturation during in vitro fertilisation (IVF) treatment, but with markedly reduced rates of ovarian hyperstimulation syndrome (OHSS). The kisspeptin receptor agonist, MVT-602, has a longer half-life than native kisspeptin-54 (1.5–2.2 h vs. 0.5 h) and has potential for development as a novel trigger of oocyte ma...

Background: Carcinoid syndrome (CS), the most common functional neuroendocrine tumor (NET) syndrome, is characterized by watery diarrhea or cutaneous flushing. While somatostatin receptor ligand (SRL) depot injections are mainstay treatments for CS, discomfort with injections and inadequate symptom relief at labeled doses are seen with many patients. Paltusotine is an investigational once-daily, oral, selective SST2 agonist in development for the treatment of acromegaly and CS...